Currently, the combination of Megadontia and Semen Demon will guarantee a death, since all companions refuse to let you feed with sharp teeth, even at 40-50 relationship. Had to reload an autosave to avoid this.
Also, I recall older versions having more options for cheats/adjusting values. I'd really appreciate being able to add/remove curses like it used to be, especially now that I've encountered two different cases of unavoidable deaths due to curses (one being the aforementioned teethy semen demon, the other being the Creature of the Night curse in layer 9, as reported by other users already).
EDIT: Forgot to mention, game performance starts to get pretty bad by the time I reach layer 8 or 9. The way I played was hoarding curses and relics without selling them, so I'm not sure if that was the reason, but I do remember that I didn't encounter this issue in the older versions.