Apparently for some people, the game doesn't create a save file, unless the game is named 'BehindTheDune.exe (or swf). Or maybe the game doesn't autosave, unless it is closed properly? In that case, quit and restart intermittently.
Most of it is avoidable and some of the tags are overstated, anyway.
futa - You are never forced to do anything with her, but if you are offended by the mere sight of a futadick, you should consult the walkthrough, because you might see it by accident.
graphic violence - You choke a woman to death with your dick, unavoidable, but it is in self-defense and you can revive her later; other than that, some dudes get blown up with grenades and you might stab someone with a knife, but it's all rather non-graphic
incest - You're probably not too bothered by this one, because that tag was there from the very beginning. All avaoidable, but there is a lot of it.
loli - Of the 1000 year old person inside a child's body variety (actually canon). Quite well developed for her age. You don't have to do anything with her, but might accidentily stumble on her in the shower (don't have her in the palace, if you want to avoid that.)
mind control - fully avoidable
rape - In the form of mind control, or if you lose the game in a specific way.
scat - Nuggets fall out in some anal scenes. This can be toggled off (poop symbol in communication room).
swinging - one unavoidable scene, optional ones? Everyone seems to have slightly different opinions on what constitutes as sharing or swinging. Better look at the walkthrough to be sure.
urination - one unavoidable scene, two optional
Everything else I would consider vanilla.
There is one unavoidable drug-fueled orgy.
Do not be deceived by the version number. Save files are ALWAYS named DuneV2-22.sol for some reason. There is no correlation with the actual version. Still, the save in the OP IS a bit outdated. Check the link in my signature. There's a set of brand-new saves in the Legacy Pack.