Pewdiepie or general memeculture not making an appearance in the game is a hill I would be prepared to die on, but I don't need to, because AFAIK none of us want that...which is not to say that there won't be any callbacks to classic scenes from cinema history... but they will be few, far between and, hopefully, well placed so that it does not feel out of tune with the rest of the game. Tossing in popular culture references for a laugh is hit and miss at best... I feel Woody Allen did it best in Sleeper, in the 70's.
That said... we're not exactly aiming for "fun" but the occasional gag might find its way in... I personally had quite a few laughs at the antics of Gasmask Dudebro... and no, I had nothing to do with writing his lines, that was all Z.