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That's the most important part of that sentence. They won't be able to give birth. I still do have a story way to give both Nat and Grace offspring with Lucas. I'm not willing to elaborate on that.
As for Anya, I was initially all in on her having kids. However some moral issues were discussed with my wife, and I started having doubts because she felt very strongly that it was wrong. Given that most of the people playing are on the good route, I'm not sure that it's something a good Lucas would do. A bad one is unlikely to mind.
The main issue is that if I did allow him to do it, there's no way to get around the immorality of it. So I'd really have to think about how I'm going to write that storyline because doing it and then not mentioning the ethics at all are going to feel scummy for a lot of people.
All I'm going to say is wait until you see where her storyline is going, I'll ask again after that. If enough people still want it, I'll give it to you. Otherwise, it's cool. Both versions are already mapped out.