Frankly I find myself not knowing who to choose. Not because there are so many LI, but when looking through the realistic lens (the game presents us with) and adding my own filters "not a bitch" and "has pussy", there's noone left. I was hopeful, with the incest tag and a promising start, there would be a mom route or sister route, but after realizing the game's aim for realism, I kind of abandoned that hope. I was just pursuing that thread to see where it would lead. Though latest developments made me think. If we still try to keep it real, they could be in trouble. In both cases they would have to hide their relationships, if not leave the state or country and go where nobody knows them. Mom and daughter could pretend to be a married couple, older and younger woman, with them having the same surname. When the daughter gets older the age difference becomes less apparent. But on the other hand they would look more alike. Thus they could at least pretend to be sisters. Then they would have to hide their relationship from the public eye. With the sister they couldn't pretend to be a married couple as she looks like a carbon copy of the MC. If the girls get pregnant, there's no magic to shield the babies from the consequences. So not that happy of an ending.

The only other characters fulfilling my criteria would be the best friend's mom and little sister. But looking at them through the lens of realism makes those options vanish. In both cases the MC, if she pursues said characters could lose her best friend. In addition Kate's marriage could be damaged, if the truth cums out. A pregnancy could be it's undoing. And a break up after an unsuccessful relationship with little sis could be really messy and cause them both emotional damage. If I turn down the requirement "not a bitch" to "slightly bitchy", that adds Vanessa as a potential candidate. Because I think there is potential. At least going by my experience with older games.
What about the rest?
Natasha is pushy, bordering on creepy. Being told off several times she still kept pestering the MC. She should file a complaint for sexual harassment. If she (the dumbass she is) wouldn't get caught with drugs.

Cleo is basically a bimbo. Big, buff, bimbo. Ignorance is bliss, I guess.

Isabella talks too much and is annoying in general.
Fiona is MC's best friend and I'd like to keep it that way. God knows the MC has very few good friends.
Siri has a great body and seems nice. Not much to say, as we have little information on her.
Vanessa's mom is ambitious and ruthless. Wants her daughter to follow in her footsteps. Like her daughter looks down at people she deems beneath her.
Vanessa's mom's girlfriend is a blond gold digger. Annoying blond sex doll. I guess the future mayor needs a big dick to blow off some steam. Which the MC could provide too, if the mom wasn't such a controlling cunt.

Lexi, a cute, pretty little futa. Unlike her cousin she is smart. If she only had a pussy to complete the package.

Zoey is just out to get some fun up and then. Too bad. Nice combination of cute and naughty.
So really no much to choose from.

But that's just how I view things. Your point of view could be different and so the features you may look for in a potential LI.