Prostitution - it's there because of the Eva scene in Ion. After that there's no more content of that type from 0.2 onwards
Drugs - Aside from the Hallucinogenic drugs and the Aphrodisiac wine we take in 0.5, there's nothing that's stronger than those, nor are there any that you can equate to "date rape" drugs. And since dev has noted aversion to rape of any sort (treats them as a negative in this game), highly doubt they will be included in the future
Blackmail - Game's blackmail content is hardly on the extreme end, the closest being the Maat scene (which one could argue might not even count if you consider that Nova was likely enjoying it deep down)
TL;DR, while the tags exist for this game, they're hardly played towards the extreme end compared to other games on this site.