Having finished the second release of the game, I had the following impressions:
1. The graphics are okay, except for a few characters that didn't look human (Mr. Lumpy, the neighbor, and Mutant Face Dude, the one who gets shot. Mutant face Dude is out of the picture, so just leave that, but if Mr. Lumpy is going to play a role, you'll want to consider re-doing him so that he looks like a human being and not a shapeless blob with a head.
2. The Story looks like it could be a highlight of the game, what with the deadbeat dad and the mystery of the mother's death. But right now the game seems filled with lots of distractions from the story, like the whiny assistant (how can she afford two salaries in a business she is just starting, anyway), the shopping trip, and the two bimbo maybe-cops. The one part where the story may have been advanced (her going on a mission with Deter) didn't tell us anything about the story. You'd be better served by getting the players involved in the story first and then add the details and new characters. The story isn't a mystery to the players; the mystery is whether there is a story.
3. The bggest problem I had with the game was the dialogue. People just don't talk like they do in the game (e.g."our destination has arrived") to the point where, sometimes, I don't even know what the person is trying to say. Read some movie scripts or look at a modern book to see how professional writers do dialogue. If there is a language barrier, get some proofreading help (I can lend a hand if you need it).
4. Get some playtesters who can catch illogical things like the heroine kicking her neighbor when he isn't breathing (as opposed to calling an ambulance RIGHT NOW), or handing a gun to someone who has never used one and not even mentioning that the gun won't work because she doesn't even know that there is a safety, let alone how to release it. No one with any sense hands a loaded firearm to another person and tells them to learn to shoot it on the job. If your current playtesters are all just patrons, consider bringing in some playtesters with experience.
As far as themes, i recommend you just stick to the currently planned ones, and forego things like futas, pregnancy, incest, bestiality, alien abduction, etc. Your plate is plenty full with what you have planned, so don't even ask if people want to overload your plate. Once you've completed the game in a first ass, you can go back and add more variation. Adding pregnancy in particular has been the breaking point for a lot of games, because it is hard to do right and it absolutely dominates gameplay when done right. Notice how FemLife development has slowed to a crawl since introducing pregnancy? And Accidental Woman? I think we will see The Fixer hit that wall in two updates or so. Don't go there.
Anyway, good luck with this game. You say in the devnotes that the story is the most important thing for you, and I think that you should keep your focus on the story. Introduce features and characters as needed to support the story, and if they aren't needed to support the story, then leave them for later. Story-based games (as opposed to feature-based games) are rare here and you could create your own niche.
Sorry for the wall of text.