"Best": probably the solo route. If I cannot have the full harem, then I can just as well be the true and tested boyfriend. Just kidding, even if with a kernel of truth hidden inside. But this really - to me - is a brother/sister love story at heart and every other person feels superfluous.
"Worst": Adriana route. I just do not like the character at all. I don't mean as a character in a novel but as a love interest. I feel nothing. She has no charms, doesn't look good (to me she's just the run-of-the-mill big tits big ass milf - I accept that many like it, there is a reason this cardboard cutout is used everywhere, but it's not for me). Also the whole story angle is wrong for my liking. The only route I stopped playing.
The others are inbetween and pretty close. Sandra is forced on you and a bit too strange for my liking, especially since I know people like her in real life (not quite like her but close enough). Lisa is a hot teen, we've seen that before as well, and there is a lack of "trio chemistry" for me. If I had to sort them I'd probably rank S before L - she is a more unique character and to me in this scenario the more fitting one, feeling like a real part of the "big happy family" and not just another fuckbuddy, which are vibes Lisa sometimes gives off.