Well yes, it seems to be sufficient when the mini-games are as stand-alone modules.
As the designer of Renpy himself states: "Each time Ren'Py starts, an infinite list of random numbers is created, and a pointer starts off at the start of this list. Everytime you take a random number, this pointer gets advanced one spot down the list".
It's like a lottery machine with numbered balls: each time a ball is drawn, it is not replaced into the lottery machine.
It seems that there are enough balls(the list is not so "infinite") for only one module which heavily uses them, at a time.
But, put those modules into the main game and this "infinite" list of random numbers will be rapidly shorten to the point that the initial distribution curve of random numbers will be affect too drastically..
But don't worry, Notty must have already solved the problem. If the module works fine as a stand alone, she will make it work the same way in the main game. Just part of her final tuning process.