I wish I knew anything about that
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I mean, this is roughly the spec I started making the game with (ram was 16gb though). But back then all animations were at 30 fps ( v0.4+ has 60fps animations), and Renpy was still supporting 32 bit systems.
You'd probably have more luck asking around Renpy forums. I just update it for the latest version before every big release, and hope for the best. Sorry, I'm not competent enough. But if you do something and it helps you, please write to me, I'll add it to the list of possible solutions.
For example I remember it helped to make sure that (if it's a laptop) the game is running on the actual GPU, not integrated graphics.