Maybe the game wouldnt be impossible if you tried different strategies rather than cheat if you cant beat a boss.
(sorry)
There is nothing wrong with taking a short cut to save time, especially if you are playing a Virgin run. The Lizard boss is extremely cheap with summoning allies, if you don't have the right setup, Karryn is out numbered 5 to one which can make this boss fight extremely unfair.
That being said, if you keep Cock desire low, and use KI attacks you should be able to knock out the Lizard boss fairly quickly with out the rope hack. Once the Lizard Boss is defeated, so is all of his allies/
Another strategy would be to increase your chance for evade / counter attack, again keep the desires low. When the enemies attack Karryn, you should be able to counter 2 or 3 of them at a time, which will make it easier to clear the screen. You'll have to do this 3 or 4 times before they stop respawning and then you can take out the Lizard boss one on one.