Less work in terms of art assets but I wonder if porting the code into an engine that probably doesn't support ren'py would get dicey. Not a programmer so I can't say
I was more thinking in the lines of recreating it in Unity.
Renpy gives you a very simple framework to quickly create a game where you click on buttons to progress a story consisting of text and pictures. But as soon as you want to do more complex things like adding a mini game or use 3D models, then it instantly gets very difficult and time consuming.
In Unity it is pretty much the other way around. There is no built in support for clicking on buttons to progress a story consisting of text and pictures, but all the other stuff is very easy to do.
Look at Venus Club for example of a game with similar logic, created in Unity. The main menu in that game is pretty much the same thing as the map in Lab Rats. You can go to the lounge, the office, Yakuza HQ or you can click on buttons to check status of stripers, how tired they are, etc.
If the author of that game comes up with a new game element that he wants to add, like for example 3D models in different poses and clothes, then he can easily do so.
Then compare it with when Vren comes up with a new idea for Lab Rats...
It is probably very much a goal in itself for Vren to try pushing the limits of what Ren'py can do, but I don't think he is doing himself any favors as a game creator by doing so.