The structure of the story will be the same. Mostly each episode will be bigger with more character interactions with each other. Let me give you a concrete example. In episode 1, the MC will be at rock bottom and he'll have the altercation with Carl as in the original version. One big difference would be that MC would not be dating Olivia. It's one of the things I didn't like about the first episode. Here our MC is supposed to be miserable and yet he has a supportive and frankly, smoking hot girlfriend. So in the reboot, he'll have broken up with Olivia and we'll start with a dropped out, alone, minimum wage worker of an MC who lives with his *ahem* landlady because for one thing, he can't afford to do otherwise and secondly because Sara is very sick. This would be the starting point.
But don't worry about the reboot just yet. It'll be a while before the spin-off gets finished.