The reasons that would happen would be one of the two issues I mentioned (long path and V-Sync in the case of Nvidia GPUs). We often find that most players tend to bury their games under multiple sub-folders if the device is being shared with someone else (keeping people from finding out you're playing a "porn game" - I actually had one player complain about that on Discord a while back).
Using a cheat mod. Cheat mods will break the game and actually add bugs to the saves.
Lesser known causes would be:
- Video card drivers not up to date.
- Anti-aliasing (needs disabled in Nvidia Control Panel >> Manage 3d settings).
- Missing
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runtimes (extract all of the files to a temporary location and run "install_all.bat". It's save to delete that folder after installing).