I don't know what environment you are technically running in but I have no issues running on windows 7, 8 or 10. I have all my games running on a separate drive (in my case F
and am running as a power user. You need permissions to your local profile (c:\user\<username>\appdata\.. ) and you need permissions to run programs from your other drive. You cannot run the game from the root of D:\, but you can from d:\games\mystwoodv0.2.0.3 (for example, mine is f:\).
Please look at the errors in the error log and that should help tell you exactly what your problem is. What errors are you seeing? Troubleshooting without errors is almost impossible.