^WWG said himself that Drew will be doing NTR. I'm 100% confident that it's going to play by the same rules as Hunter. If you keep it off, it will continue as if you choose the choice that skips it.
Also, Hunter says "I miss having a son". So it's implied he knows about the sex change since CH 6. Also Ophelia had said "I don't have a brother". Both imply that they know what Drew did. Though you would only know this conversation if you saw CH 6 bad end. Ophelia didn't like to talk about it.
Edit: Here's the important line, just so those that don't want watch NTR can see.