Since I paused my game in the meantime, I've been rethinking a lot of things and learning from the issues I had. I am halfway considering 3D. Or at least some sort of hybrid. A major issues is screen space, and with 2D you can only really scroll, but 3D always allows panning which would allow for a lot better feeling design.
3D women would be hot but really expensive and 2D obviously has it's own charm.
What is your opinion on basically HD sprites? 2D animated girls but the level is actually polygonal and you can pan the camera a bit. Like how Fallout Shelter looks.