most actual AV softwares are really thorough with executable files, and if anything scanned doesn't match a "safe" pattern, you get an alert. that's like it's supposed to be. with various scan techniques, the AV can even try to predict the possible behaviour of a scanned application (heuristic scan), but the more it tries to predict, the higher the possibility of a false positive. reading the future isn't exact. i've set my AV to a rather high scrutinity, so i get even more alerts.. when that happens, i give the files in question a deep scan.
for RPGM/Ren'Py/Unity and other similiar platform based games, i generally run those in a sandboxed environment. Comodo can do that rather easy, but is a bit complicated to configure "just right" on your needs. others have more convenient one-click solutions but i prefer this one for this computer.
