Game doesn't load with the patch installed for me - freshly downloaded from the link in the OP at the same time as downloading the patch.
I also had a similar errorlog if I tried to patch in the ES3 bepinex plugin to find the encryption key for the save file.
I get this error log:
Fatal error. System.AccessViolationException: Attempted to read or write protected memory. This is often an indication that other memory is corrupt.
Repeat 2 times:
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at Interop+WinHttp.WinHttpOpen(IntPtr, UInt32, System.String, System.String, Int32)
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at System.Net.Http.HttpWindowsProxy.TryCreate(System.Net.IWebProxy ByRef)
at System.Net.Http.SystemProxyInfo.ConstructSystemProxy()
at System.Lazy`1[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]].ViaFactory(System.Threading.LazyThreadSafetyMode)
at System.Lazy`1[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]].ExecutionAndPublication(System.LazyHelper, Boolean)
at System.Lazy`1[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]].CreateValue()
at System.Lazy`1[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]].get_Value()
at System.Net.Http.HttpClient+<>c.<get_DefaultProxy>b__15_0()
at System.Threading.LazyInitializer.EnsureInitializedCore[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]](System.__Canon ByRef, System.Func`1<System.__Canon>)
at System.Threading.LazyInitializer.EnsureInitialized[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]](System.__Canon ByRef, System.Func`1<System.__Canon>)
at System.Net.Http.HttpClient.get_DefaultProxy()
at System.Net.Http.HttpConnectionPoolManager..ctor(System.Net.Http.HttpConnectionSettings)
at System.Net.Http.SocketsHttpHandler.SetupHandlerChain()
at System.Net.Http.SocketsHttpHandler.SendAsync(System.Net.Http.HttpRequestMessage, System.Threading.CancellationToken)
at System.Net.Http.HttpClientHandler.SendAsync(System.Net.Http.HttpRequestMessage, System.Threading.CancellationToken)
at System.Net.Http.HttpMessageInvoker.SendAsync(System.Net.Http.HttpRequestMessage, System.Threading.CancellationToken)
at System.Net.Http.HttpClient+<GetStreamAsyncCore>d__51.MoveNext()
at System.Runtime.CompilerServices.AsyncMethodBuilderCore.Start[[System.Net.Http.HttpClient+<GetStreamAsyncCore>d__51, System.Net.Http, Version=6.0.0.0, Culture=neutral, PublicKeyToken=b03f5f7f11d50a3a]](<GetStreamAsyncCore>d__51 ByRef)
at System.Runtime.CompilerServices.AsyncTaskMethodBuilder`1[[System.__Canon, System.Private.CoreLib, Version=6.0.0.0, Culture=neutral, PublicKeyToken=7cec85d7bea7798e]].Start[[System.Net.Http.HttpClient+<GetStreamAsyncCore>d__51, System.Net.Http, Version=6.0.0.0, Culture=neutral, PublicKeyToken=b03f5f7f11d50a3a]](<GetStreamAsyncCore>d__51 ByRef)
at System.Net.Http.HttpClient.GetStreamAsyncCore(System.Net.Http.HttpRequestMessage, System.Threading.CancellationToken)
at System.Net.Http.HttpClient.GetStreamAsync(System.Uri, System.Threading.CancellationToken)
at System.Net.Http.HttpClient.GetStreamAsync(System.String)
at BepInEx.Unity.IL2CPP.Il2CppInteropManager.DownloadUnityAssemblies()
at BepInEx.Unity.IL2CPP.Il2CppInteropManager.GenerateInteropAssemblies()
at BepInEx.Unity.IL2CPP.Il2CppInteropManager.Initialize()
at BepInEx.Unity.IL2CPP.Preloader.Run()
at BepInEx.Unity.IL2CPP.UnityPreloaderRunner.PreloaderMain()
at Doorstop.Entrypoint.Start()