Wow, this whole original post, I mean WOW. Finally, a fellow true gamer among the hordes of generic VNs and 3D "western style porn games" enjoyers. I've gone through many good picks on this list, and it was quite satisfactory. I'm not very much into standart straight action, which the list consists mostly of, but there's some kinky stuff which I like. Many "chibi" games there though, which is a bit sus
But who cares, it's all fiction right. Other entries I would add would be:
Oh So Hero! Cool 2D platformer with 3D background and juicy animations (including threesomes), and different animations depending on whether you defeated an enemy, or they defeated you. Kinda reminds me of old PS1 games. The gallery is accessible just by clicking ESC, what more do you want? S/A tier for me. (super gay and furry though, but I'm into that)
Tales of Androgyny Come on, you can't have a "must play" list without this one. The combat system is fun and unique, the art style - just awesome. IMO, it's the closest you can get to DnD in lewd games. S-tier for sure, legendary title. (also gay, but with tons of futas)
Nekomancer This particular dev has other games with similar style, but I think this one is their best. Awesome 2D pixel art. It's a short one though, so IMO only B-tier. Simple top-down magic shooter. Charge a special attack to charm enemies! (super gay)
Tailbound A top-down RPG-maker kinda adventure game. Find objects and fit them in the right places to progress the story. Animations and variety of them rock, I like pixel art. It's simple, relatively short, but that's the beauty of it. A-tier for me. (super gay and furry)
KobolKare A fun furry sandbox 3D game. Raise your own kobolds, change their bodies to your liking and have them breed each other or yourself. If you buy it on steam, you can play this game online with other people LOL. Early in development, I would put it in the B-tier.
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It's an unusual entry even for me, but I gotta admit, if I had to choose between this and Second Life, I'd probably go for this one. It's 3D, you can make futas if you want, there's quite a decent character creation system, there's a variety of poses, but it's heavily RP-based, so you gotta be a horny keyboard warrior. C-tier, but good for what it offers.
Mage Kanade's Futanari Dungeon Quest What a title, say that 5 times fast. In this one, I'm not quite into that, since the protagonist isn't submissive, but I gotta admit, it's a very fun game, it's top-down, where you gotta shoot enemies down while you finish levels, even with decent boss fights. You can play it with one hand too! Very good art and animations. A-tier for sure.
Hunt and Snare It's one of those very promising 3D games with open world that end up being lackluster because indie development is hard LOL. D-tier, but props for trying. Basically a furry game with a good customization system, where the bulk of the game is hunting and taming wild furries (hence the name), but you also got a story, a quest system, characters, dialogues. Imagine if someone tried to make Skyrim in the Overgrowth world setting, but failed to achieve both.