If this happens on loading a save file, there's a glitch somewhere in it the engine doesn't like. It's complaining of a Direct3D fail, which on a new copy of an OS may mean finding the older DirectX (DX11 or 10) as the game has traditionally had issues playing nice with DX12.
A fatal error loading a save happens a fair bit if you're using the Radiant Save Editor linked to a page or five back. It also comes with a built-in backup tab so you can keep a clean copy of the original save in RSE in case the edit and save goes inexplicably wrong you can load from the backup & retry your edit.
![Wink ;) ;)](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
(nudge Cross Zero)
If you're getting that right as the game loads, You may need to find the Radiant AppData folder, decide if you want to back up your saves & config data, then retry. All else fails, wipe both the game & app data, then do a clean load of the whole game. Also check your video card & OS for which version of DirectX it's got, installing an older version "under" the current DX version may solve the crashing.
Have you bought the Mutt Hut from Cassie in the village? Without it there's no hybrids, with it there seems to be a set percentage chance of getting a hybrid that may vary on the game startup state. Using the "Max Trait Level" cheat seems to increase the odds of hybrids.