What I do is I take the save and split it off into as many copies as there are ways to win, not including dead or escaped Chosen, and play each in a different way so that I have ones that follow both what benefits me as the player in future loops and what I want to see as a relationship between each.Damn....... that's a tough dilemma. I don't really want any of my Chosen to be enemies, mostly for roleplay reasons.
But those Distortion bonuses are so very useful...
I usually reserve my no distortions, total vulnerability breaks save for having unbreakable friendships across the entire team and the rest focus on the distortion without regard for relationships as long as I get all three as Forsaken. The one with all unbreakable friendships is the one I use as my main save.
This avoids having to sacrifice one for the other, but it is a bit more real time consuming.