If you don't mind speculation, my guess would be any of the following:
More of the mayor's family corruption
More of the principal's family corruption
More Sophia corruption
But all at once would be an enormous update, far bigger than anything he's released to date.
In deference to my guess I'd actually like to see more work done on Mrs Robinson and the Coffee Shop girl. Those two are actually due for an update. Or, I don't know, just polish off some of the "in future releases" actions. Or the subway scenes. That'd be good too.
The Principal's family would feel like completing the last update to some degree, and be nice so we can take her to Utopia.
I think another 'faction' of support might be more likely than the mayor's family for now...
I would like to see Heather's ex's new ex show back up, she was cute. Maybe she can start working in that club or something. Give it a reason to exist other than a bad way to make money.
It has been a while for the neighbor and her daughter, but it also has been a while since we got anything for the aunt and cousins too.
Some new Utopia scenes might be nice too.
...Not that I expect to be right.