I just spent the week exploring the new City map. It is absolutely fucking confusing and unfair with all the enemies and the lack of lighting. New Structural weapon is really good once you get to a full kit; you can spam .338, although it still sucks (you will get overgassed easily after a few shots, it's rare and is barely better than .45 APN against Corpos.
While I'm working on an updated walkthrough (as R19 changed so much), here are the current settings I'm running right now:
High, High, Very High, FSR 3 (but I assume DLSS implementation is also decent), and Lumen Off. This produces around 60-70 FPS in all areas except for City where it's about 30-40 around the Emission Zone and the body dump area near the West exit.
Gameplay settings will work well as a balance with Medium difficulty, 1-1.2 damage multiplier (I play on 1.12), Low Gunpart Damage, Weak/Slow Tentacles, Weak Psychosis effects, Max Traders, and unlocked Body Modifications.