*noddities*
I mean I know really it shouldn't matter that much given the genre of H5 but...it sorta does? I think anything that is immersion breaking is an issue and since I've set out to make a game with a more grounded feel to it, anything that breaks that feel is a problem.
So long as I don't see a space ship arriving at a space station, pointing towards it, engines going full throttle (so max acceleration as it arrives) and then magically stopping as it arrives.... I'm good

.
But what can/will break it depends on the person. The correct science can break it for someone expecting the wrong (see above.. and why it's almost ALWAYS done), and the wrong knowing the right. You can't win
Do love The Expanse for getting much of the gravity stuff correct. Now there's an example of using science giving plot points. All the combat is physics based with the leading, hard burns, Gs etc.
Other than Mass Effect i haven't played many scifi game who actually try to take time to make some sense from their ingame science. Most just briefly mention things, similar the way Star Wars games do.
Hell i played the Anno 2250 from ubisoft and i don't remember the game ever bothering to explain much of the tech behind the ships and the lunar colony you needed to build.
That because Star Wars isn't really sci fi (the movie, let alone the game heh). It's fantasy based, with space weapons. You've got your Knights (Jedi), wizards (the more magical jedi powers), princess, pirates etc. In general the science should have something directly to do with the plot for sci fi (why so many sci fi dystopian future movies on how tech might twist things). Gattaca (DNA checking), Moon (would be a spoiler), Altered Carbon (mind swapping). Then you need to know the science as it's part of the plot, if it's just a gun to shoot someone with, not so much.
And much of it would be problematic to explain. Like what is a phaser. Is it a light weapon, because if so we shouldn't see it like it's done on screen. So better leave it, and keep the cool visuals.
Ahhh, nothing like science and movies for a Friday night post beer heh.
edit: thinking about games. SOMA and Control are two games that are pretty good with science stuff (one more than the other being based on reality) as being explained and ingrained into the gameplay. But yeah, certainly not many.