There are many exceptions - some of the stories to be told center on one of the above.IMO there are a few deal breaker tags people either really like or really hate. I think Devs when creating a game should know the main ones before creating a story or game and make them avoidable. Main tags that always gets talked about is NTR, Lesbian/Bi content, DOM, Harem, and incest. People either love them or hate them so i think they should be a way to avoid each of those Tags. I know some of them are hard to avoid depending on the story you want to tell but mostly they all can be avoided if you are truly trying to tell a story not just a porn game.
Ultimately, the dev has to decide what their story will be about, and stories on this forum will generally include some sexual content. If a dev is looking at their game as a startup, they'll probably be swayed heavily by whatever the people willing to invest in them want. If they are looking at it as a creative outlet, hopefully they will not. Devs who realize that they are creating games including a lot of content they don't personally find interesting are devs who are likely to burn out, leaving their games incomplete and abandoned.