hmmm i see, my problem is that i spend so much money buying raw supplies that i cannot re-earn selling serum, bcs i need to pay stephanie
I know I am jumping into this conversation a bit late but this might help.
I put 1 point in Charisma and Focus. I put 3 points in intelligence. 4 points int research nothing in the rest. 1 point into foreplay nothing in the rest.
The first week concentrate on research.
Each day you come into work spend 45 points doing "small talk" with Stephanie save between hand so you can retry in case it gives you the stupid chat for a few minutes. This way you can build up her love. Do this when she first comes in that way you can earn back the energy over the time you work. When you get home your energy will be full. Also tell her you appreciate her hard work each time. This is also going to help boost her happiness.
When you get home small talk your mom. You want to build her up so you get the alternate pay stuff early on.
By the time the second week roles around you should have your mom and Stephanie fairly high and be able to produce a Serum that gets 120 for each one sold and only cost 40 resources and time to make.
Once you have that hire someone for the 4 departments outside of research.
The first Serum you should sell:
Primitive Serum production, High Concentration Drugs, High Capacity Design, Basic Medical.
You should also be able to make several goals by this time with your mom and Stephanie. Put those points into increasing energy. Don't bother increasing other skills till you have 200 energy. You may make other goals put those into intelligence and research. They are the primary trait you need at the start.
Also you can use that Serum with Stephanie when you ask her to forward your research.
The reason I don't bother making Serum in that first week or making any less powerful ones it consume more of your time and money than it is worth.
The fact is some Serums just aren't worth wasting time to make. Take when you move to the Improved Serum production. It costs 70 supply units and time to make them. So you need to make sure the product sells for a good bit more or you won't make as much profit. It costs almost 2 times the time to make them and supply as the previous one. So you need a serum that makes 2 times as much or it isn't worth it.
In truth putting the effort into getting that High Capacity Design to a much lower chance of side effect can pay off quite a lot.
Once you hire people to work in the departments when they come into work take the time to go around and compliment them. Spend a some points small talk till you have 10 love then flirt with them instead. You will gain 3 love and raise sluttiness up temp +2. If you have Raised Charisma up more you can increase the love you get. But as I said your focus should be on research raising it up to start.