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djustmie From what I understood about this game, the more you sell a serum, the lower it's price will get. It's basic supply and demand. If you keep selling 1000 beers every week, the price will decrease. However, if you sell 200 beers, 100 wine, 100 vodka every week, the price for each of them will not decrease as much.
What I'm trying to say is that each serum has a set of positive attributes (Mental, Physical, Sexual, Medical) and a set of negative attributes (Flaw, Attention). If you keep selling the same serum with 8 Mental points and 9 Medical points, the price of that serum will decrease to the point where you can't pay the salaries and various upkeep (serum production upgrades*). To avoid this, create 2 or more serums with different properties and sell them in an alternating manner. For example create another serum with high Physical and/or Sexual stats. That way you can sell 20-30 serums from the first type (Men+Med) and after a few days you sell 20-30 serums from the second type (Phy+Sex). If you hire a person which generates good Market reach, they will make sure the prices will restore faster.
*do not unlock tier 2 or 3 serum production until you unlocked several profitable traits and designed profitable serums.
Also don't forget to decrease the salary of your workers (weekly performance review or through punishments). The salaries are the biggest drain on your cash. The best way to decrease the salary without losing Happiness/Love is to make sure the sluttiness is below 20 (1 heart), choose punish > threaten to fire > Cut pay. This way she will be thankful for not losing her job and you will get happiness and obedience. After you decrease the salary to 25$ you can start increasing her sluttiness and have fun.
One last tip: don't forget to do a quick save before looking at resumes and before Stephanie calls you to say that a serum design is ready. That way you can rollback and get a different roll of potential employees or avoid creating a serum with flaws (assuming the flaw chance is not 100%).
If I was inaccurate with any information, please let me know so I can correct it.
PS: another tip...compliment/insult the work of your employees daily to get free happiness/obedience.