In my dogmod, you can look in the info folder and check out the changes document where i list the lines of script that i changed to adjust the values for resistance. You can open the script.rpy with notepad++ and make it "half strength" and go from there. The is still a little bit of a challenge since the rng chance and the resistance do combine to make it a little challenging. The workaround is to keep track of what you did and go for the highest possible use of the serum and then use rng in your favor so you don't have to keep going for the same event to raise the slut score. Remember that using the same "show me your boobs" at the "steph lab morning event" will raise her resistance. So if you can quicksave, quickload to get the random even you need, then it's not that big of a challenge if you can track what you've done and manage your time well. It's just the combination of the 2 that can catch you off-guard.