Finished my first playthrough trying to bang just about everything that moves, and still got an awesome Chloe ending... Totally worth it.
I know some people are into pregnancy scenes, but I could care less, if I have to stay completely loyal to Chloe and not drill Ana twice, Abigail once, the Teacher three times, and Rose twice, to get it, it's not worth it.
My ending was still happy, Chloe didn't cheat with anyone, I still picked her as best girl, and got to drill everyone I wanted along the way (no Eve or Candy, but I didn't care for them anyway).
Going back before the cab choice to see if I can still see the Anna and Lisa endings if those exist already... If not going back to the Rose choice to pick the Cuck choice and see if the threesome ending with Chloe and Rose, or pure Rose endings are worth throwing away the MC's man card.