There is at least one hidden scene and some other stuff that can be missed.
Also for example i'm about start all over again and i want to rush through most of the game up to the last 2 or 3 updates worth of content as fast as possible, and a guide helps with that.
Absolutely, there are many events/choices that have to have been done/made in order to enable some scenes and paths. It's quite complex actually. Examples:
-Shaving her self in the bath tub (instead of letting Nicoles bf do it) disables a lesbian scene with Nicole in v0.92.
-Staying at Mike's place over night (in v0.92) disables a scene with Fred.
-The hidden NTR scene on day 10 is very easy to miss if you do not know where to look.
-There is also a hidden scene with Daniel that can be missed if you are not careful
-Not to mention if you want to play loving wife path -> opens up an entire different game almost...
Read the walk through and you see many of the ins and outs...