I wrote a review originally stating the game might become unwinnable, but after looking through it again, I think I may have exaggerated it. Modified it (for like the 5th time, I may be liking this game a little too much despite its flaws).
The more Marle gets raped, the weaker she will get to sexual attacks in general, which make battles against mooks harder, incentivizing evading battles over killing mooks.
However, the leveling of the game is very lenient (lategame enemies can level you once per battle), and Marle learns all her skills quite quickly. Unless you did nothing but throw Marle onto dicks and tentacles from the very beginning and never won a battle, you should still be capable of clearing the game, I believe.
Is it bad game design? ...Honestly, yeah. I won't deny that. However, I personally give it a pass for being good thematic design, because obviously the MC is going to get weaker to sex the more she does it. That's the entire idea behind corruption. We see it in H-anime and manga all the time where a once great hero just becomes a nympho wreck. Other games do it through H-scenes, while this game does it through gameplay.