what's the best card combination + inherent skills to each character??
I wouldn't go so much with any card combo, although that's completely up to you (I used very few cards during testing, other than to make sure they were working correctly). What you could do is make sure that your staff has the experience in their skills for higher level guests (IOW, don't take on higher level guests with low staff levels, they'll fail every encounter). Also, make sure the guest rooms and facilities are upgraded, take advantage of the office upgrades, staff skills and make sure all your girls have items that you will find in the attic, lake and general store.
There is a list of all of the items, cards, traits and upgrades in my guide linked in OP if you need to make a choice on what to go with.