The mapping file (which is basically a text file) changes the relationships with the MC, Julia and Amber. It has no other affects on the game other than that. What you omitted in your OP was whether or not you're playing from the beginning (tutorial) or from an already established playthrough (i.e: continuation from a previous version) or using a cheat mod/cheat engine. So with little information to go on, I have no way of instructing you on what you can/need to do. Having said that, as others have already mentioned, if you're in the middle of the tutorial, the cheats and statistics screens will unlock after your first guest (Karen McQueen) successfully checks out.
That screen doesn't "randomly" lock or unlock. It's going to be locked at first up to playing through the tutorial, then unlock (and remain that way throughout the rest of the game) afterwards. If it's occurring randomly, then it sounds like you're using a cheat mod/cheat engine which will bug your game.