That choices aren't bad per se, there are differences yes.
Choosing Li it will help you with Tamara and other things along the story ( but, there's always a but...
are you willing to romance her? i did and I can say it was worth it, but that's my opinion).
The Gorgons or the association are two completely different paths so they are both good, they are different.
Choosing the Gorgons allow you to meet all the non-humans creatures, while the association all the humans one ( plus some magical creatures along the line), they are both paths worthy to be played make a save there and play both.
The last choice, well that is up to you, I can say that choosing lady Singh doesn't close the path with Oriana ( I will not say any more, I don't want to spoil you more), and it gives you more but with a price
( the death of Matheus, but you will get to make an alliance with the Rakshahsa).