All good, I'm just throwing theories around to see what sticks, and this one didn't. But the principle of a character changing in 20 odd years is not revolutionary, especially when there's a whole bunch of implied drama. The last three years haven't been kind to my family and I can see the results in us, so 20 odd years of establishing some form of cartel might leave people looking very different. Emilio's a great example of this.
All of us are noticing different things, and with each other playing devil's advocate we might be able to throw away some dead ends, or we might find other openings. I think few games have made me wonder what will happen next like thes two in any regards.
Vanessa's heterochromia might be as a result of (relatively) benign disease instead of inherited, and it's a red herring to wonder who her parents are.