Yup.
My idea of it would be him and MC perhaps end up going on a mission together, and they discover a plot by the other Familes of Big 5 (sans DeLuca) in a plot to overthrow the DeLuca Family.
They try to warn Cordia and Wilfred, but fall in a trap and is cornered.
Antonio somehow buys time for MC to escape and warn the Family, but is completely surrounded.
Antonio: Bring it on.
After several minutes of fighting (with many fallen enemies around him), Antonio is on his knees, injured.
Yet guns are still aimed at him from all around.
Other Dons of Big 5: (to Antonio) Any last words?
Antonio: Hope, please look after Isabel and my Family..... (then shots are fired, and Antonio slumps to the ground).
Now something like that, I could really get behind (even though there's probably a lot of holes in that little write, as many as holes in the cheese
)