Maybe, maybe not. I dont know how
HopesGaming wants to handle the friend/netori route down the line.
But i would definetly want, that the current relationship status is also present in the main story (e.g. the flirty interaction between MC and Luna during the shootout in the warehouse).
Since Isabella is less often present in the main story than Luna and Gracie, i think it is easier to handle multiple routes with her.
Luna and Gracie however are often together and have a closer relationship, different relationship routes with them would probably increase the workload by a lot.
I also think a harem route (at least with Luna and Gracie) would better suit MC's character, since it was stated multiple times by other characters, that they feel like MC is a low key womanizer (without realizing it himself).