Some things I've found.
-if grabbed while crawling locks Mr. S in an infinite tearing of garments animation.
-the spidermites grab attacks if allowed to run through or deflected lock you out of interacting with anything.
-Sometimes using a save point removes articles of clothing.
-the spidermites will get confused and just kind of stand there spinning after being tossed off.
-creating vagacite or analite, not picking it up from the stirrer, and reloading a save causes it to lose the pick up option.
-the bed destroyed by the tentacle is restored on a save reload with the tentacle just chilling in it.
-the little flying pitcher plants fly up too high to aggro you most of the time.
-opening the greenhouse and then saving bricks your game save, also makes the inside of the mansion invisible if walking through it before a reload.
-you have to have the keycard in hand after opening the greenhouse to trigger the "boss" cutscene.
-you can glitch out of the greenhouse by walking around the outside of the planters on the first floor.
-repairing the statue with the broken piece and analite seem to still be bugged, even after reading all the notes for clues on mounting.