I generally don't use groceries much I tend to use the uber pill that cures everything, but I buy lots of booze particularly at the beginning to unlock the shops secret stash, because you get a point of affection with our chubby buddy with each sale.Because you don't need 80 alcohol, and it takes time to click. I do buy 50 or 100 groceries at a time.
Seriously though, it makes sense to have lots of booze in the house if you want to awaken the alcoholic in your sis... who ever heard of anyone getting wasted on 3-5 units of alcohol (A light weight maybe, but not a seasoned drinker like our darling sibling).