lol, Yeah I mention The Twist in The Twist. Because I copied my own response I made from other thread. Nothing wrong with promoting a game in it's own thread.
So more animations early game mom-son. lemme think...
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Last Hope might be what you are looking for. You are with your mom, sister and aunt on a spaceship that runs into problems and out of gas. For some reason the engine runs on fuel that can be synthesized from male semen. And you are the only guy. So you start getting everyone to help you refuel the ship. Has animations and free roaming. Game is time based, so it benefits you to learn routine of target.
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The Company is a HTML game using real images. Your a corrupt chemist that gets hired by an evil corporation that is involved in creating and selling slaves. You develop and use your chemistry to expedite the process, and you can take some home to use on your family. Has multiple paths with each female, depending if you choose to remain masculine/feminine, make her sub or dom, keep her to yourself or share, etc. I think mother has 8 different endings last time I looked.
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S.H.E.L.T.E.R. has very fast relations with mom and sisters, since it is a post-apocalypse spoof where you dad wants you to repopulate the world, but he can no longer bear children. So he pushes you to impregnate everyone in the family. Not very open world, and I do not remember if the Dev added animations or not.
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A Zombie's Life and
Urban Demons developed by Nergal. You get involved with your close relatives pretty quickly, and it escalates as the story progresses. AZL has you sharing baths with mom and spying on her sleeping pretty quickly, and as you grind affection bathtime turns into handjob etc. And if you get her to watch drunk before bed she slowly starts visiting you at night to take advantage of your body. UB has similar structure, where you can earn favor and then share use of bathroom together, with more and more actions to do together. You can also flush your heart pills down the toilet and convince your mom that morning wood is bad for your heart and she should handle it. So things can start pretty early, if you know what you are doing to trigger these events. Has some basic animation in scenes.
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Zombie's Retreat and
Zombie's Retreat 2 are spiritual siblings of Nergals AZL. It is implied it is the same zombie outbreak, but different people in different location sorta. Has basic animation in scenes.
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Town of Passion same structure as ZR. Just different world and characters and story.
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Take Over is pretty good. Dystopian world where you live in a tyranical dictatorship. You get a job at a company that produces a potion to brainwash people and you smuggle some out. The intended story is for you to take over the country I think. But naturally you start at home. I dont remember if it has animations though. If not, might get some.
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Lab Rats and
Lab Rats 2 have you interning with a chemistry teacher so you can steal materials for your own potions, corrupting everyone. If you know what you are doing you can cut the grind a bit and get to mom in reasonable time, though sister and lab staff are usually easier due to frequent access to them. No animations though. Can feel grindy, but should be simply to edit save file for more potions.
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Man of the House is a good game. You slowly corrupt your all female family, until you are the Man of the House. I forget if it has animations, I think it does but it has been a while. Game has a lot in it, including hidden collectables to unlock bonus gallery content.
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Sweet Affection is a little grindy, but you can get cameras in every room and there are scenes to unlock everywhere in the house with each female. Has some animation.
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Strangers in a Strange Land is relatively short game, but has a little in it to make it worth a look. Older title by Y3DF.
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Summertime Saga is a decent game with growing content. Openworld and has some limited animations. Takes a minute to unlock mom or sis. But if you know what you are doing, doesnt take too long. Aunt is faster.
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The Tyrant is abandoned, but honestly there is enough content there to make it worthwhile. Your dad is an undercover cop with drug dealers, and the cover has you and your family all pretending to be involved in the drug trade too. So you decide to join the gang and dominate the females, corrupting them with drugs. You can choose the puritan route, no drugs and be a good son. I honestly dont know how that plays out, but it is an option.
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Snow Daze is a decent game. Cypress Zeta worked hard to put full vocals in the game. I forget if it has animation, I think it might. Can be slow to corrupt the females. But ourcomes, artstyle and the sound is very well developed.
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Young Maria is another HTML game with real pictures. This time MC is female. You can go lesbian with mom or get it on with bro or dad. Also has classmates, co-workers, beach and park encounters, and farm animal interactions if you choose that.
I may be missing some titles. But it is difficult to remember games involving mothers and have animation. There are many many more titles among the JRPG genre, but those usually require different website to get the game and sometimes (not always) have english or MTL files somewhere.