If you ask me, there's nothing really gained by having the chick be from Totally Spies. If you haven't watched the show (like I have) then you have zero attachment to the character whatsoever, and even if you have, the connection seems barely there.
With that being said, the potential decisions to be made about it are interesting. You could expand on the parody further with a better connection to the source material, but to me that'd make me lose more interest since I don't see much worth in playing a parody of a series I don't care for, even if the erotic content is good.
I feel like it'd be better to make the heroine an original character, perhaps with a similar secret agent/spy backstory, and give a better reasoning for why she's on this resort island getaway filled with dickgirls. Maybe she's there to investigate something but gets caught up with all the fucking. Could even go a different route, she was lost at sea and washed ashore on the island.
The fact that some of them use masculine pronouns is... interesting, I suppose. Especially when they're wearing feminine hairstyles and lipstick. "Freddy" seemed to be referred to as both the Pastor's daughter and son in the same conversation, which was a little odd, if not accurate to a strange degree.