A lot of the examples of transhumanism based media presented in this thread are not good representations of it. Cyberpunk 2077, Deus Ex, Ghost In The Shell. Transhumanism as a philosophy and as a movement is about technology making the world better and allowing humanity to evolve into a more perfect form. The examples given in this thread more accurately fall into the genre of cyberpunk, which usually involves taking the positive promise of transhumanism, bending it over a table, and raping it until it's bleeding from every hole. Media that presents transhumanism accurately as a positive movement for human flourishing is... rare, to say the least, probably because sunshine and daisies don't make a very compelling plot compared to corruption and human misery.
So, to anyone not familiar with transhumanism as a concept, take the examples from this thread and remove all the parts that make you weep for the future, and that's a more accurate portrayal of transhumanism as a theoretical concept. Whether that kind of technology in real life will fulfill the transhumanist promise or look more like a cyberpunk dystopian hell hole is an open debate and only someone with a time machine could tell you for sure.
Edit to add, in case anyone is curious, I thought of a piece of media that I think is a really great example of the positive side of transhumanism. It's not a game, sorry, but it's worth it. It's a novel called Blindsight by an author named Peter Watts, about humanity making first contact with an alien species. Virtually every character in the novel is modified in some way and it's treated as a positive thing, overcoming deficiencies and adding capabilities. It's also under creative commons license so if you search around for it it's easy to download for free.
