Not so easy, but then as usual, which rpgmaker games did you have experience with ?
TLS aka The Last Sovereign use resist and feeble along status skills to make battles more involved.
Then, most battle don't matter much, with enough characters they are plenty of options as some exemple make clear (the non finished sucuby in the Incubus Emperor place, then, the some of the planes beings who attack over MDS, magical defense.. Probably the most undefended there is.
Map size ? Its related to uses, to visit a town, explore an area, aren't possible with renpy. Not directly at least as using plenty of renders to open path to the next area (bastard girl for example).
I have played almost all RPGM out there, and they do suck. The only thing that keeps me going is the story, which benefits nothing from combat and similar time waste mechanics. The only RPGM companies that can make it work and be somewhat tolerable or even fun at some rare cases are Japanese companies. All western RPGM that I have played just suck and would be much better at Renpy.
Two examples.
Area69 and Family Venture. One has a billion different locations to explore, memorize, with events at specific times and so on and fort. The other has only 4 map locations, with reusable event location. The second is the correct approach.
You don't need 1 trillion different locations that adds absolutely nothing. I have played several western RPGM games with not only too big maps, filled with empty space to increase the walking time, but also with completely redundant and actually retarded quest lines.
For example, a game ask you to go to the western part of the town to pick an unimportant item. then ask you to return to your home, then send you to another map at south, and then makes you return to the initial place at west. All this back and fort for nothing.
I can name a very popular game, Lilly of the Valley. Horrible and impossible to play without the Renpy remake, but there are many games much worse than Lilly actually.
Smart games uses very small towns, with a single building for multiple functions, teleport, and objective questline.
That only appears in Japanese RPGM, that's why they're the only ones tolerable to play.
Overall it's an awful system, especially in the hands of a clueless developer, without any expertise of level design. Even worse when they want to 'add gameplay hours' by senseless questlines with a lot of walking back and fort.