The only reason I'm doing Lisa's path is because Jade is attached to her, so I don't have a problem with them being stuck together. I'm hoping picking just Jade is an ending path/option, just for variety's sake, but the easiest/safest path would be just to have both or none at all.
Overall, Selina seems to be the best character with the best development. I didn't care much one way or the other because it was all sex but she's really interesting beyond that. The Rosa dynamic makes it really black and white about what to do.
Jane also has some good development with the potential for a lot of drama.
Anna doesn't have much story compared to the others, so it's hard to judge.
My rankings nobody asked for would be
1 Lisa + Jade
2 Selina
3 Jane
4 Just Lisa
5 Anna