While I enjoy the card game, might I suggest smoothing out the resource transitions a bit? Maybe I've had bad luck, but it feels like once you reach a certain threshold, you get almost no opportunities to use the previous resource (though that's partially because the opportunities you do get cost seven or more, usually), while the new resource rapidly scales up into requiring five or more to buy a new card. This seems particularly true of Submission, where you don't have any opportunity to buy Submission cards before you reach 50 tf, but once you do, almost everything seems entirely Submission-themed.
I haven't cracked open the code to look or anything, but currently, between tf 10-20 feels like a good blend at the moment, where you have several opportunities to buy Flirts with Thoughts to change over your deck to the new resource - it's just that it's really easy to miss out on that point if you're unlucky on your draws, the buy pile, or getting tf'd too quickly. Especially because only a few Brainstorms are changed to Flirts at first - if you don't get a chance to buy the card that requires Thought and offers Flirt (I don't recall the name at the moment, sorry), or miss out on the chance to buy a couple of Flirt+s, it can be really hard to afford the later Flirt cards.
Another alternative might be to just include more cards that accept the previous resource in return for the new one - I don't think this is an issue for Submission, which has several cards that accept Flirt right away, but for Flirt, I can only think of a couple of cards that accept Thought for Flirt, one of which comes up relatively late in the cycle.
It'd probably make things too easy, but it would also be nice if we had a way of ditching the "basic" cards (Brainstorm, Flirt, Submit, Bimbo Pills) entirely - there's a lot of them, and they have an unfortunate way of cropping up when you really wish one of your better cards would be drawn. Especially now that we have a way of deleting older cards from our deck, increasing the ratio of the "basic" cards to your newer cards.
Then again, maybe I'm just a bit too quick to buy cards, and I should just stop shopping so much. Especially at the lower levels, given how Thought becomes obsolete fairly quickly, and thought-based tfs are fairly weak.
By the way, a question about the ditz cards; when you add a ditz to the deck, does it immediately overwrite one of your old Thought cards, or do you have to play it before it removes the Thought card from your deck? If it doesn't, what happens if you end your turn before playing the Ditz?
By the way, while the game is fun, it might be a good idea to include an auto-win button alongside the auto-lose button (Perhaps label it something like "I love these kinds of games!", to establish that the main character just so happens to have played a game like this a few dozens of times in the past) - unless you have games for the other routes, it feels strange that this is the only one that requires you to play an entirely different type of game to progress, and it's kind of long. While I enjoyed spending a couple of hours experimenting with a few different strategies, it kind of distracted me from the real game. And since it's somewhat reliant on luck, if I had to win it four times in a row to find the last story route... I could easily see myself getting frustrated if I kept botching the final "match the final target number" segment, and having to start from scratch.
Then again, I don't really like the psychologist route and love Emily to bits, so it doesn't matter that much - I'm just a bit of a completionist, and have a few thoughts as to how it fits into the rest of the game.
As an irrelevant aside... Until the latest twist, I had idly thought that Emily had brainwashed Alex into being her friend to begin with (just given her casual approach to brainwashing in general). I also thought that Emily preferred women and girly guys, and thought "Hey, wouldn't Alex be cuter if I made him a bit more girly?", only to forget each time that she'd already done that, making the problem worse and worse while she only meant to cause him a minor problem.
Even if neither of those was actually the case, it's nice to see that she actually is just as careless with the consequences of her actions as she first appeared.