The Special Chemistry and Progress quests often require Nick to be staying over. But getting
that to trigger appears to be problematic and grindy. Hopefully that will improve with the latest updates to NPC interactions
For Special Chem, a "Take Pill" button
should appear at the couch after 2300. Best to wait till 2230 or so then incrementally wait 10 minutes until the button appears. But since you are waiting for Nick and Julia to finish in the bathroom, it may not trigger till after 2320.
You may also need to "Sleep Until Morning", not Sleep 3 or 6 hours.
Lucius Logan - It should autosave when you "Sleep Until Morning". Otherwise I have no idea. I have the opposite problem - I'd like to delete saves