If you care about gameplay at all, I suggest starting new playthrough on "Crysis" difficulty (or whatever it's called in our version) as soon as you get become familiar with in-game systems and mechanics. It requires some grinding in the early stages but later it's totally manageable. Game really shines on this difficulty or rather - it's a proper RPG where you have to manage enemy weaknesses, your abilities and gear or even boss mechanics. You can still get somewhat overpowered but even then, you can get messed up by a group of random monsters if you don't pay attention and just spam "attack".
