I mean, I have no horse in this race but I feel like between straight up NTR and futanari/trans/intersex women in a vanilla/harem capacity I'll take the second any time, especially since NTR usually does involve some major non-con/dub-con issues on the female character's part, and is speficially done from the POV of the cucked dude rather than, like, normal cheating which is usually more consensual on the woman's part and done through her viewpoint.
Like, it's a woman with a dick, get over it, does anyone here have any idea how popular trans porn alone is, people want to fuck them/want to get fucked by them, lots of fucking people if you look at the charts, the main issue here should be, like, how the self insert character is "cucked" by the woman with a dick instead, which is not dissimilar to him getting cucked by any other character getting a magical mind control dick, Ophelia being the one doing it is only topycal due to her characterization within the game itself and her taunts to Sterling during the unfortunately short lived Femdom section where she claims she would fuck all his fuck buddies if she had a dick just to spite him.
I guess the idea that this is, like, NTR Involving a woman with a dick is what making people feel more conscious, especially given the themes of mind control and the evident "she is far better than him" message, is what's making everyone go spare over it, in which case, again, if you don't like it don't read the what if? It's non canon and it's entirely based on the women being mind controlled too so you can't even say "well but that means they might cheat too" yeah if you had a mind controlling magical dick come on, you can't even go "well, this is happening in some alternate universe tho" in one alternate universe Catherine went mad and set the house on fire, I don't see people going wild over it because it turns her into a serial killer for killing her whole family (which is more of a recurring trait for her since that would be the SECOND bad end/what if where she kills someone).