Since we're still throwing out wild theories, I had another thought. What if it's like Murder on the Orient Express and they're ALL responsible in some way.
Marcus is responsible due to his experiments, Mike is responsible due to his inexperience (the manual can only get you so far), Trisha... I don't know, we haven't seen much of her but just because she's a horny woman, that doesn't mean she doesn't have a dark side, Amanda due to her iron grip of the station and Kelly, well, I think she's just caught between a rock and a hard place. Due to being an ensign, she was left there as a token military force but I think she also has orders to spy on Amanda.
Individually, these may be minor inconveniences but coupled together, it may have created the situation that is present on Ophion.